The center collaborates with a group of strategic partners to ensure the system's effectiveness and achieve its objectives. These partners include:
- Ministry of Commerce
- Ministry of Industry and Mineral Resources
- Ministry of Municipal, Rural Affairs, and Housing
- Ministry of Health
- Public Security (Traffic Department)
- Civil Defense
- Public Health Authority (Weqaya)
- Zakat, Tax, and Customs Authority
- Saudi Red Crescent Authority
- Consumer Protection Association
- Public Health Authority (Weqaya)
- Vehicle Safety Center